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beagle狗im蒿甲醚花生油注射液,每天一次,连续15天。共观测了一般临床指标16项,血液学指标10项,血液生化指标17项,尿液8项,心电图,眼底检查及病理学检查51个器官组织。主要中毒反应是体温呈间隙性升高、食减、无力、粘液血便,Q—T间期延长,外周血象和骨髓涂片显示骨髓造血功能受损,以红系成熟障碍为主,CK、ALP、及GOT升高。病理检查,见内脏组织器官充血、出血、水肿,尤以胃肠道为著,并出现变性糜烂,肝细胞变性,灶性坏死,肾小球囊腔内有蛋白和红细胞渗出。这些变化停药后可自行恢复。外周网织红细胞障碍的指征出现最早,是最敏感的化验指标,可以认为蒿甲醚中毒的主要靶器官是骨髓造血组织。上述中毒表现随剂量的增加而加重,32MKD(mg/kg/day)组比19MKD组中毒严重,并有3/4的动物死亡。小剂量组6MKD未出现明显的中毒反应,可视为基本安全剂量。
beagle dog im artemether peanut oil injection, once daily for 15 days. A total of 16 clinical indicators were observed, hematology 10, 17 biochemical markers, urine 8, electrocardiogram, fundus examination and pathological examination of 51 organs and tissues. The main toxic reaction was intermittent increase in body temperature, diet, weakness, mucus bloody stool, Q-T interval prolongation, peripheral blood and bone marrow smear showed bone marrow dysfunction, erythroid maturation disorder, CK, ALP , And GOT increased. Pathological examination, see organs of the visceral hyperemia, bleeding, edema, especially in the gastrointestinal tract, and degeneration of erosion, degeneration of liver cells, focal necrosis, glomerular cysts with protein and erythrocyte exudation. These changes can be self-healing after withdrawal. Peripheral reticulocyte signs appear the earliest, is the most sensitive laboratory indicators, can be considered the main target organ artemether poisoning is bone marrow hematopoietic tissue. The above poisoning performance aggravated with the increase of dose, 32MKD (mg / kg / day) group was more severe than 19MKD group, and 3/4 animals died. Small dose group 6MKD no obvious toxic reaction, can be regarded as the basic safe dose.