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目的:观察大剂量维生素B2防治偏头痛的疗效性与安全性。方法:成人无先兆偏头痛70例,随机分为观察组(维生素B2组)35例,给予维生素B2100mg,每天3次口服;对照组(氟桂利嗪组)35例,给予氟桂利嗪5mg,每天1次口服,治疗2个月。观察治疗前后两组头痛程度、持续时间、发作频率及药物不良反应。结果:维生素B2组无不良反应,显效率51.4%,总有效率88.6%,与氟桂利嗪组比较,差异不显著(P>0.05)。结论:大剂量维生素B2防治偏头痛疗效好,安全性好。
Objective: To observe the efficacy and safety of high-dose vitamin B2 in the prevention and treatment of migraine. Methods: 70 adult migraine without aura were randomly divided into observation group (vitamin B2 group) 35 cases, given vitamin B2100mg orally 3 times a day; control group (flunarizine group) 35 cases given flunarizine 5mg , 1 day orally, for 2 months. The degree of headache, duration, frequency of seizures and adverse drug reactions were observed before and after treatment. Results: There were no adverse reactions in vitamin B2 group, the effective rate was 51.4% and the total effective rate was 88.6%. There was no significant difference between the two groups (P> 0.05). Conclusion: The high dose of vitamin B2 prevention and treatment of migraine has good curative effect and good safety.