胆固醇肉芽一种特定的临床疾病,而是用以描述对胆固醇结晶产生的组织学反应的组织学专门名词。耳部的胆固醇肉芽肿最先由anassé于1917年描述,但早在1869年Politzer氏的论著中业已提及此种病变。直到Ranger(1949)再次报告时,才为耳鼻喉科医师所注意。本病的命名较多,比较混乱,曾有“蓝色鼓膜”(Shambaugh,1929)、“特发性血鼓室”(O′Donnell,(1949)、“黑色胆脂瘤”(Birrell,1956)及“浆液性乳突炎”(Sheehy,1956)等称。回顾这些文献,作者们报告中所描述的组织病理学变化,即是胆固醇肉芽肿。后来相继有报告在慢性化脓性中耳乳突炎、慢性渗出性中耳炎及某些耳部手术后的病例中,都看到有胆固醇肉芽肿病变发生。Friedmann(1956)报告,在各种耳部慢性 Cholesterol granulation is a specific clinical disease, but a histological term used to describe the histological response to cholesterol crystallization. Ear granulomas of cholesterol were first described by Anassé in 1917, but such lesions were already mentioned in Politzer’s work as early as 1869. It was not noted by otolaryngologists until Ranger (1949) reported again. The disease is more naming and confusing and has been described by Shambaugh (1929), O’Donnell (1949), Birrell (1956) And “Sheehy (1956).” Review of these documents, the authors describe the histopathological changes described in the report, namely, cholesterol granuloma. Later, one after another reported in the chronic suppurative otitis media Inflammation, chronic exudative otitis media, and some post-operative cases of ear surgery, have seen cholesterol granulomatous lesions occurred Friedman (1956) reported in a variety of ear chronic