目的 :评价克洛曲片对癌性疼痛的镇痛效果。方法 :采用多中心开放研究的方式 ,观察克洛曲片对 111例癌痛患者用药 63 1次的临床效果 ,分析用药次数、近期用镇痛药史及其他因素对克洛曲片镇痛效果的影响。结果 :克洛曲片的首剂总有效率为 92 .8%。平均 3 5min起效 ,1h达到最佳缓解状态 ,疼痛缓解时间可持续 6h以上。克洛曲片对中度和重度疼痛的有效率无显著差异 ,但重度疼痛患者起效较快 ,缓解时间较短 (P <0 .0 5 )。连续 10次用药后 ,完全缓解 (CR)率的降低和部分缓解 (PR)率的增加均有显著意义 (P <0 .0 1) ,缓解时间也显著缩短 (P <0 .0 1) ;近期应用二、三阶梯镇痛药史 ,也明显降低克洛曲片的CR率 (P <0 .0 1)。克洛曲片的不良反应以恶心、头晕、乏力较多 ,但均可耐受。结论 :克洛曲片对中度和重度癌性疼痛的镇痛效果确切 ,安全性好 Objective: To evaluate the analgesic effect of clenbuterol on cancer pain. Methods: A multicenter open-label study was conducted to observe the clinical efficacy of cloacae tablet in 111 patients with cancer pain. The analgesic effect of cloacapril tablet was analyzed with the frequency of medication, the recent history of analgesics and other factors Impact. Results: The first dose of cloacae tablets was 92.8%. An average of 3 5min onset, 1h to achieve the best state of relief, pain relief time sustainable 6h or more. There was no significant difference between the two groups in the effective rate of moderate and severe pain, but patients with severe pain developed faster and had shorter remission time (P <0.05). After 10 consecutive doses, the reduction of complete remission (CR) rate and the increase of partial remission rate (PR) were significant (P <0.01), and the remission time was significantly shortened (P <0.01). The recent application of the second and third ladder painkiller history, but also significantly reduce the rate of clenbuterol CR (P <0.01). The adverse reaction of cloacae nausea, dizziness, fatigue, but can be tolerated. Conclusion: The Kro patches have definite and safe analgesic effects on moderate and severe cancerous pain