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目的:研究50MV高能X射线照射患者时光核反应产生的正电子发射核11C、15O在PET的显象技术及信息,探讨用该信息定量研究照射的肿瘤生物靶区准确度和剂量分布情况。方法:50MV的X射线照射圆柱体模后快速置于PET上扫描显像和数据处理,确定射野轨迹和照射区大小并与物理射野大小比较,确定11C活度分布,研究11C显像位置和显像强度与照射靶区和照射剂量的关系。结果:50MVX线2Gy照射可在PET上获得清晰的11C显像图,并能准确分析出照射轨迹和照射位置,精度达1.0mm;在射线离轴方向上,11C的活度曲线与TPS计算的剂量曲线一致;而在射线轴向上,11C的活度曲线与TPS计算的深度剂量曲线差别很大。结论:50MVX线2Gy照射体模光核反应产生正电子发射核11C可在PET上显像,显像的位置可对照射靶区的准确度进行生物学验证。
OBJECTIVE: To study the imaging techniques and information of positron emission nuclei 11C and 15O produced by time-nuclear reaction in 50MV high-energy X-ray irradiation and to explore the accuracy and dose distribution of the irradiated tumor bio-target area with this information. Methods: 50MV X-ray irradiation was applied to the PET scans and the data were processed quickly. The trajectory and area of the radiation field were determined and compared with the size of the physical field. The distribution of 11C activity was determined. The location of 11C imaging And imaging intensity and irradiation target area and irradiation dose relationship. Results: The clear radiographs of 11C were obtained on 50MVX line with 2 Gy irradiation, and the irradiation trajectory and irradiation position were accurately analyzed. The accuracy was 1.0mm. In the off-axis direction, the 11C activity curve and TPS The dose curves are consistent; however, in the radial direction, the activity curve of 11C varies greatly with the depth dose curve calculated by TPS. CONCLUSION: The positron emission nucleus 11C produced by 50MVX line 2Gy irradiation and phantom photonuclear reaction can be visualized on PET. The imaging location can be used to verify the accuracy of irradiation target.