目的比较氟马西尼与纳洛酮抢救苯二氮类药物急性中毒的临床疗效。方法选取2012年3月至2015年1月收治的急性苯二氮类药物中毒患者120例,随机分为观察组和对照组,各60例。两组患者均给予常规维生素C解毒、洗胃、导泻,抗生素和速尿利尿治疗,观察组患者加用氟马西尼,对照组患者加用纳洛酮。结果治疗后30 min和1,4,24 h,观察组患者的催醒效果明显优于对照组(P<0.05);两组患者的昏迷程度评分比较,差异有统计学意义(P<0.05);观察组患者的用药剂量明显少于对照组患者,平均意识恢复时间和住院时间均明显短于对照组患者,所用费用明显少于对照组,差异均有统计学意义(P<0.05);观察组总有效率为98.33%,高于对照组的85.00%(P<0.05);两组患者均未出现严重不良反应。结论在抢救苯二氮类药物急性中毒患者时,氟马西尼的催醒效果和催醒速度要优于纳洛酮,且缩短了患者的住院时间,减少了住院费用,值得临床推广。 Objective To compare the clinical efficacy of flumazenil and naloxone in rescue of acute poisoning of benzodiazepines. Methods A total of 120 acute benzodiazepine poisoning patients who were admitted from March 2012 to January 2015 were randomly divided into observation group and control group, 60 cases each. Two groups of patients were given routine vitamin C detoxification, gastric lavage, cathartic, antibiotics and furosemide diuretic treatment, the observation group plus flumazenil, the control group patients with naloxone. Results After 30 min and 1, 4 and 24 h of treatment, the awakening effect of the observation group was significantly better than that of the control group (P <0.05). There was significant difference between the two groups in the degree of coma (P <0.05) ; The dosage of observation group was significantly less than that of the control group, the mean recovery time and hospitalization time were significantly shorter than the control group, the cost was significantly less than the control group, the difference was statistically significant (P <0.05); observation The total effective rate was 98.33%, higher than that of the control group (85.00%, P <0.05). No serious adverse reactions occurred in both groups. Conclusion In the rescue of patients with acute poisoning of benzodiazepines, flumazenil is superior to naloxone in waking up and awakening speed, shortening the length of hospital stay and reducing the cost of hospitalization, which deserves clinical promotion.