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[目的]探讨铅锌矿区职业人群体内锌、镉负荷及脂质过氧化物酶的含量。[方法]采用横断面流行病学研究方法,对146名某矿区作业工人和54名非矿区人群进行健康检查和现场采集发样及血样,检测其发镉、发锌、血镉、血锌及血清脂质过氧化酶超氧化物歧化酶(T-SOD)、丙二醛(MDA)及谷胱甘肽氧化酶(GSH-Px)的水平,并进行统计学分析。[结果]接触组发锌、发镉、血镉均高于对照组(P<0.01或P<0.05),血锌、T-SOD、GSH-Px活性均低于对照组(P<0.01或P<0.05);接触组MDA水平与对照组差异无统计学意义(P>0.05)。接触组中工龄≤10年者,其发镉及血镉水平均低于工龄11年以上者,差异有统计学意义(P<0.05)。[结论]铅锌矿区职业人群长期接触镉后可改变体内T-SOD、GSH-Px、MDA水平,导致矿区职业人群体内脂质过氧化作用增强,抗氧化能力降低。
[Objective] The research aimed to discuss the zinc and cadmium load and the content of lipid peroxidase in professional population in lead-zinc mining area. [Methods] With the methods of cross-sectional epidemiology, 146 workers in a certain mining area and 54 non-mining areas were inspected for health check-ups and samples collected on site for blood samples, hair cadmium, hair zinc, blood cadmium, blood zinc and The levels of serum lipid peroxidase superoxide dismutase (T-SOD), malondialdehyde (MDA) and glutathione oxidase (GSH-Px) were measured and statistically analyzed. [Results] The contents of zinc, cadmium and cadmium in the exposed group were significantly higher than those in the control group (P <0.01 or P <0.05), while the activities of Zinc, T-SOD and GSH-Px in the exposed group were lower than those in the control group <0.05). The level of MDA in the exposed group was not significantly different from that in the control group (P> 0.05). In the contact group, the workers who were less than 10 years old had lower levels of cadmium and blood cadmium than those of more than 11 years of service. The difference was statistically significant (P <0.05). [Conclusion] Long-term exposure to cadmium in occupational population in lead-zinc mining area could change T-SOD, GSH-Px and MDA in vivo, leading to the increase of lipid peroxidation and the decrease of anti-oxidative capacity in occupational population of mining area.