虽然慢性胰腺炎的病理已经十分清楚 ,但其早期的致病机制尚不明确。慢性胰腺炎的一般特点为纤维化 ,慢性炎症和胰腺实质的消失 ,这些特征会随着疾病的发展而逐渐出现 ,同时还伴有急性胰腺炎的症状。一些专家认为慢性胰腺炎继发于急性胰腺炎。另一些则认为慢性胰腺炎首先发生 ,急性胰腺炎则在此基础上发生。慢性胰腺炎所引起的疼痛可通过许多机制发生。增高的胰腺压力可干扰神经 ,影响血流 ,改变 pH值 ,并引起有毒物质的潴留 ,激活动作电位。组织的破坏和炎症介质的释放可刺激传入神经。甚至 ,炎症可直接破坏神经 ,引起神经性疼痛。掌握疼痛在外周和中枢神经系统中的神经冲动传递路径才能找出减轻胰性疼痛的有效方法。疼痛可以通过内脏、迷走、脊神经和膈神经等外周神经传递。它也可通过脊髓的背侧神经束和脊髓丘脑束中继传递。因此寻找到新的治疗胰性疼痛的方法是可能的 Although the pathology of chronic pancreatitis has been very clear, but its early pathogenesis is not yet clear. The general characteristics of chronic pancreatitis are fibrosis, chronic inflammation and the disappearance of the parenchyma of the pancreas, which gradually develop as the disease progresses and are accompanied by the symptoms of acute pancreatitis. Some experts believe that chronic pancreatitis secondary to acute pancreatitis. Others think that chronic pancreatitis occurs first and acute pancreatitis occurs on that basis. Pain caused by chronic pancreatitis can occur through many mechanisms. Increased pancreatic stress can disrupt nerves, affect blood flow, change pH, cause retention of toxic substances, and activate action potentials. Tissue destruction and the release of inflammatory mediators can stimulate afferent nerves. Even inflammation can directly damage the nerves, causing neuropathic pain. To master the pathways of nerve impulse transmission of pain in the peripheral and central nervous system can we find an effective way to reduce the pain of pancreas. Pain can be transmitted through visceral, vagal, spinal nerve and phrenic nerves and other peripheral nerves. It can also be relayed through the dorsal nerve bundle and spinothalamic tract of the spinal cord. Therefore, it is possible to find new ways to treat pancreatic pain