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以牛蛙离体椎旁神经节为标本,单个方波电刺激节前纤维,细胞内记录B细胞的动作电位,在正常情况下节前单个刺激,在B细胞发生一个动作单位,刺激与反应的关系是1∶1。灌流皮质醇(0.01μmol/L~1μmol/L)、皮质酮(1μmol/L)、孕酮(0.1μmol/L)、17β-雌二醇(0.001μmol/L)、醛固酮(0.001μmol/L)及胆固醇(0.1μmol/L),比较它们对神经节B细胞突触传递的快速作用。结果显示,皮质醇可使170个B细胞中的52个发生突触传递阻断,另外有4个细胞出现增强效应;皮质酮可使48个B细胞中的17个发生阻断;孕酮可使37个B细胞中的15个发生阻断;17β-雌二醇可使21个B细胞中的8个发生阻断;醛固酮对B细胞的突触传递无明显影响;胆固醇可使21个B细胞中6个产生增强效应。实验结果表明,皮质醇、皮质酮、孕酮及17β-雌二醇对牛蛙交感神经节部分B细胞突触传递具有快速阻断作用,尤以孕酮的作用最显著。盐皮质激素(醛固酮)对B细胞突触传递无明显影响,而胆固醇对B细胞突触传递有增强效应。
Taking the isolated paravertebral ganglion of bullfrog as specimen, a single square wave was used to stimulate the preganglionic fibers. The action potentials of B cells were recorded intracellularly. Under normal circumstances, a single pre-nociceptive stimulus occurred in B cell, which stimulated and responded to The relationship is 1: 1. Corticosterone (0.01μmol / L ~ 1μmol / L), corticosterone (0.1μmol / L), 17β-estradiol (0.001μmol / L) and aldosterone 001μmol / L) and cholesterol (0.1μmol / L), and compared their rapid effects on the synaptic transmission of ganglion B cells. Results showed that Cortisol blocked the synaptic transmission of 52 out of 170 B cells and enhanced the effects of 4 other cells. Corticosterone blocked 17 of the 48 B cells. Progesterone Blocked 15 of 37 B cells; 17β-estradiol blocked 8 of 21 B cells; aldosterone had no significant effect on B cell synaptic transmission; cholesterol caused 21 B Six of the cells produce a booster effect. The experimental results show that cortisol, corticosterone, progesterone and 17β-estradiol have a rapid blocking effect on the synaptic transmission of some B cells in the sympathetic ganglion of bullfrog, especially progesterone. Mineralocorticoid (aldosterone) had no significant effect on synaptic transmission of B cells, while cholesterol increased the synaptic transmission of B cells.