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目的 证实母乳EGF分泌量的变化是对早产儿加速生长和成熟的一种适应性反应 ;比较人乳、新鲜牛奶以及新生儿奶配方中的EGF含量。方法 使用放射免疫分析法 ,测定了 5 7份人初乳 (分别来自分娩早产儿和足月儿的母亲 )、4种新鲜牛奶和 8种基于牛奶的新生儿配方奶中的EGF含量。结果 早产儿奶的EGF水平 (2 8 2± 10 3nmol/L)明显高于足月儿奶 (17 3± 9 6nmol/L)。母乳EGF含量与其分娩的新生儿胎龄和出生体重呈负相关。新鲜牛奶的EGF水平 (13 8- 18 2nmol/L)与足月儿奶相当 ,但低于早产儿奶。非水解蛋白质配方奶的EGF浓度明显低于人奶和新鲜牛奶。水解蛋白质配方奶的EGF浓度在可测范围之下。结论 早产儿奶中EGF的高含量可能代表着一种与早产儿加速的生长发育相适应的代偿机制 ;由于配方奶中的EGF不足甚至缺乏 ,故应提倡用母乳喂养自己的婴儿。
Objective To confirm that changes in breast milk EGF secretion are an adaptive response to accelerated growth and maturation in preterm infants; compare EGF content in human milk, fresh milk, and neonatal milk formula. Methods Radioimmunoassay was used to determine EGF levels in 5 7 human colostrums (mothers with preterm and term infants), 4 fresh milk, and 8 milk-based neonates. Results The level of EGF in preterm infant milk was significantly higher than that in term infants (28 ± 10 3 nmol / L) (17 3 ± 96 nmol / L). Breast milk EGF content and birth of newborns gestational age and birth weight was negatively correlated. The EGF level of fresh milk (13 8- 18 2nmol / L) is comparable to full-term milk but lower than that of premature babies. The EGF concentration of non-hydrolyzed protein formula was significantly lower than that of human milk and fresh milk. The EGF concentration of hydrolyzed protein formula is below the measurable range. Conclusions The high level of EGF in preterm infant milk may represent a compensatory mechanism that is commensurate with accelerated growth and development of premature infants and should be encouraged to breastfeed their own infants due to inadequate or even insufficient EGF in formula milk.