抗白血病药的神经毒副作用较为常见并十分重要,临床医师对静脉应用大剂量阿糖胞苷引起的神经毒性已有较足够认识。然而,对鞘内注射阿糖胞苷(ITAra-C)后引起的神经毒性(上行性脊髓病、脑瘸等)却认识不足。近几年来,国外文献屡次报道。我院自开展儿科血液病工作以来先后发生4例,此合并症起病较急,进展迅速,预后亦凶险,应引起专 The neurotoxicity and side effects of anti-leukemia drugs are relatively common and very important. The clinician has already had sufficient understanding of the neurotoxicity caused by intravenous high-dose cytarabine. However, neurotoxicity (ascending myelopathy, cerebral palsy, etc.) caused by intrathecal injection of cytarabine (ITAra-C) is poorly understood. In recent years, foreign literature has been reported several times. Four cases have occurred in our hospital since the pediatric hematology work. The complications of the complications are acute, rapid progress, and the prognosis is also dangerous.