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目的 观察急性心肌梗死 (AMI)患者血清肌钙蛋白I(cTn-I)浓度的动态变化 ,探讨其与AMI近期预后的关系。方法 选择AMI患者76例 ,采用美国××公司的ACS180SE化学发光免疫系统 ,以双抗体夹心法测定cTn -I浓度 ,观察cTn-I浓度及动态变化 ,并观察住院期间心脏病变和并发症发生情况。结果 除1例外 ,其余75例AMI患者cTn-I浓度均高于正常 ,敏感性为98.7 %。有10例AMI患者cTn -I浓度持续升高时间>10d,10d后cTn -I浓度波动于 (1.50～3.11)ug/L之间。发生心衰、严重心律失常等并发症明显高于cTn -I较快恢复正常者 ,P<0.05。观察期间有30例AMI患者出现左心衰 ,cTn -I持续升高时间为 (9.47±4.70)d ,而不发生左心衰者cTn -I持续升高时间为 (6.71±1.77)d ,P<0.05。cTn-I持续升高时间在7d内住院期间无1例死亡 ,7～10d内有2例死亡 ,>10d有5例死亡 ,P<0.05。结论 cTn -I浓度持续升高 ,缓慢下降 ,为近期预后差的一个独立危险因素 ,需加强监护 ,采取积极的治疗措施
Objective To observe the dynamic changes of serum cardiac troponin I (cTn-I) concentration in patients with acute myocardial infarction (AMI) and explore its relationship with the short-term prognosis of AMI. Methods Sixty-six AMI patients were selected. The chemiluminescence immunoassay of ACS180SE was performed in × × Company of USA. The concentration of cTn-I and the dynamic change of cTn-I were measured by double antibody sandwich method. The incidence of heart disease and complication . Results The results of cTn-I in other 75 cases of AMI patients were all higher than normal except for one case. The sensitivity was 98.7%. In 10 AMI patients, the cTn-I concentration continued to increase for> 10 days, and the cTn-I concentration fluctuated between (1.50 and 3.11) ug / L after 10 days. The incidence of heart failure, severe arrhythmia and other complications was significantly higher than that of cTn-I recovered quickly, P <0.05. During the observation period, 30 patients with AMI had left heart failure, the duration of cTn-I sustained increase was (9.47 ± 4.70) d, while the duration of persistent cTn-I rise was (6.71 ± 1.77) d, P <0.05. There was no death in cTn-I within 7 days of hospitalization, 2 deaths in 7 ~ 10 days and 5 deaths in> 10 days, P <0.05. Conclusions The concentration of cTn-I keeps increasing and slowly decreasing, which is an independent risk factor of short-term prognosis. It is necessary to strengthen supervision and take active treatment measures