动脉粥样硬化的免疫学发病机制的研究,早年从单核-巨噬细胞、T 细胞及免疫球蛋白和补体等方面进行不少工作,发现动脉粥样硬化的发生发展有免疫因素参与。近年来国外从MHC-Ⅱ类抗原在动脉血管壁细胞表面上的表达及众多细胞因子对动脉内皮细胞和平滑肌细胞的多种作用进行了研究,包括IL-1对内皮细胞的作用有利于血凝和血栓的形成;IL-1促进血管平滑肌细胞和内皮细胞生长;TNF 对血管和炎症作用与IL-1相似,并影响脂质溶解;IFN 在动脉粥样斑块形成中可能是一种抑制因子。 Atherosclerotic immunological pathogenesis of early years from mononuclear macrophages, T cells and immunoglobulins and complement a lot of work and found that the occurrence and development of atherosclerotic immune factors involved. In recent years, foreign countries from the MHC-Ⅱ antigen in the arterial wall cell surface expression and a number of cytokines on arterial endothelial cells and smooth muscle cells of a variety of roles were studied, including the role of IL-1 on endothelial cells is conducive to blood coagulation And thrombus formation; IL-1 promotes the growth of vascular smooth muscle cells and endothelial cells; TNF has similar effects on blood vessels and inflammation as IL-1 and affects lipidolysis; IFN may be an inhibitor of atherosclerotic plaque formation .