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对镇咳神口服液进行药效学实验研究。结果表明 :镇咳神口服液对氨水引起的小鼠咳嗽及枸椽酸引起的豚鼠咳嗽均有明显的抑制作用 ;能增加小鼠气管内酚红的排出量 ,增强毛果芸香碱对小鼠的流涎作用 ,其作用随剂量的增加而加强 ;对二甲苯引起的小鼠耳廓肿胀也有明显的抑制作用 ;还能明显抑制豚鼠磷酸组胺所致的哮喘反应。急性毒性试验结果表明该药的MTD大于 2 0 0g/kg ,未见明显毒副作用。
The pharmacodynamic experimental study of Zhenke Shen Oral Liquid was conducted. The results showed that Zhenkeshen Oral Liquid significantly inhibited cough induced by ammonia in mice and cough induced by citrate in guinea pigs; it increased the excretion of phenol red in the trachea of mice and enhanced the salivating effect of pilocarpine on mice. , Its role with the increase of the dose to enhance; xylene caused by ear swelling in mice also has a significant inhibitory effect; also significantly inhibited guinea pigs caused by histamine reaction. The results of acute toxicity test showed that the MTD of the drug was greater than 200 g/kg, and no obvious toxic side effects were observed.