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采用自身前后对照,13例新诊断T2DM并高血糖(FPG≥11mmol/L);短期2周甘精胰岛素强化治疗(三餐配合使用速效胰岛素);停药随诊观察。结果:治疗后C肽曲线下面积及胰岛素分泌指数明显增加;胰岛素抵抗指数明显改善。复诊患者中最长的已经3个月不用药物,仅靠控制饮食和运动就能很好的控制血糖。结论:对伴明显高血糖的初发T2DM,短期甘精胰岛素强化治疗可以快速、稳定控制血糖,显著改善胰岛B功能和胰岛素敏感性。
Thirteen patients with newly diagnosed T2DM and hyperglycemia (FPG≥11mmol / L) were treated with self-control. Short-term insulin glargine was administered for two weeks (three meals with fast-acting insulin). Follow-up was followed up. Results: After treatment, the area under C-peptide curve and insulin secretion index increased significantly; insulin resistance index improved significantly. Patients in the referral have the longest of 3 months without drugs, just by controlling diet and exercise can be very good control of blood sugar. CONCLUSIONS: Short-term intensive insulin treatment of T2DM with high blood glucose in newly diagnosed T2DM can rapidly and stably control blood glucose and significantly improve pancreatic islet B function and insulin sensitivity.