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为探讨四氢呋喃(THF)按触者血、尿和呼出气中THF浓度能否作为生物监测的指标,并评价此3项指标在现场应用的价值,作者对某磁带厂接触THF的58名男工进行了调查。接触工人年龄21～48岁,平均工龄7.2年,车间空气中THF浓度范围0.64～48 mg/m~3。58人中有10人的吸烟量为中等(<10支/d),4人为大量。所有研究对象均无心肺肝肾及其它慢性病。同时选取无THF接触史的8名医院工作人员为对照。呼出气、血和尿的收集方法及其中THF的分析方法如下:(1)收集工作班后5～10 min内的呼出气300 ml,集气环境中THF浓度低于321.4μg/m~3。测试前集气管加热至80℃,并用新鲜空气冲洗,抽取100μl注入气相色谱仪。测定于集气后2 h内进行。检测限为128.6 μg/m~3。对照样品进行
In order to investigate whether the concentration of THF in blood, urine and exhaled breath of patients with THF can be used as indicators of biological monitoring and evaluate the value of these three indicators in the field, 58 male workers in a tape factory contacted with THF We conducted a survey. Exposure to workers aged 21 to 48 years, the average length of service of 7.2 years, workshop air THF concentration range 0.64 ~ 48 mg / m ~ 3.58 people in 10 smokers were moderate (<10 / d), 4 were large . All subjects were without heart, lung, liver and kidney and other chronic diseases. In the meantime, eight hospital staff members without history of exposure to THF were selected as controls. The method of collecting exhaled breath, blood and urine and the analysis method of THF therein are as follows: (1) 300 ml of expired air is collected within 5 to 10 minutes after the working class is collected, and the THF concentration in the collected atmosphere is lower than 321.4 μg / m 3. Before testing, the trachea was heated to 80 ° C and rinsed with fresh air. 100 μl was injected into the gas chromatograph. Determination of gas within 2 h after the collection. The detection limit was 128.6 μg / m ~ 3. Control samples were performed