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目的探讨血清骨桥蛋白(osteopontin,OPN)水平与慢性阻塞性肺疾病(COPD)的关系。方法 COPD急性加重期患者26例作为A组,平均年龄(62.32±4.11)岁;COPD缓解期患者23例作为B组,平均年龄(61.38±4.32)岁;C组18例,为年龄、性别匹配的吸烟者对照组;D组18例,为年龄、性别匹配的不吸烟者对照组,检测各组血清骨桥蛋白水平并比较分析。结果 A组患者血清OPN水平最高,较其他三组比较,差异具有统计学意义(P<0.01);B组患者血清OPN水平次之,较C,D组比较,差异有统计学意义(P<0.01);D组血清OPN水平最低,较C组比较,差异有统计学意义(P<0.05)。结论血清OPN水平可能是反应COPD病情变化的早期指标,并且与病情的严重程度有关。
Objective To investigate the relationship between serum osteopontin (OPN) level and chronic obstructive pulmonary disease (COPD). Methods Twenty-six patients with acute exacerbation of COPD were enrolled as group A. The average age was (62.32 ± 4.11) years. In COPD patients, 23 patients were in group B, with an average age of (61.38 ± 4.32) years. In group C, 18 patients were age-matched Of smokers control group; D group 18 cases, age and sex matched non-smoker control group, detection of serum osteopontin levels and comparative analysis. Results The level of serum OPN in group A was the highest, the difference was statistically significant (P <0.01), the level of serum OPN in group B was the second, and the difference was statistically significant compared with group C and D (P < 0.01). The serum OPN level in group D was the lowest, which was significantly different from that in group C (P <0.05). Conclusion Serum OPN level may be an early indicator of the change of COPD, and is related to the severity of the disease.