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测定５４例正常人、６８例肺癌、３３例肺内炎症病人血清糖链抗原５０（ＣＡ５０）含量。结果表明，肺癌血清ＣＡ５０含量显著高于正常人和肺内炎症，且肺癌Ⅰ期即有明显增高，Ⅲ期增高更为显著。行根治术后其血清ＣＡ５０含量较术前显著降低（Ｐ＜０．０１）；术后复发者又复增高，行姑息术或放化疗后略降低，且不久又复增高。以血清ＣＡ５０值９ｋＵ／Ｌ为阳性诊断界值，对肺癌诊断的敏感性为８０．９％，特异性为９５．４％，阳性预计值为９３．２％，肺癌伴癌性胸腔积液其血清、胸液ＣＡ５０含量，均明显高于结核性胸腔积液，差异有极显著性（Ｐ＜０．０１）。提示血清和胸液ＣＡ５０含量测定在肺癌、癌性胸腔积液的诊断、鉴别诊断和监测中均有一定实用价值。
The levels of serum carbohydrate antigen 50 (CA50) in 54 normal subjects, 68 patients with lung cancer, and 33 patients with pulmonary inflammation were measured. The results showed that the serum CA50 content of lung cancer was significantly higher than that of normal people and inflammation in the lung, and there was a significant increase in the first phase of lung cancer and a more significant increase in phase III. After radical resection, serum CA50 levels were significantly lower than those before surgery (P<0.01). Postoperative recurrences were increased again. After palliative surgery or radiotherapy and chemotherapy, the serum CA50 levels were slightly decreased, and soon afterwards they increased again. With a serum CA50 value of 9 kU/L as a positive diagnostic cutoff, the sensitivity for the diagnosis of lung cancer was 80.9%, the specificity was 95.4%, and the positive predictive value was 93.2%. Lung cancer with cancerous pleural effusion Serum and thoracic fluid CA50 levels were significantly higher than those of tuberculous pleural effusions, with a significant difference (P<0.01). It is suggested that the determination of CA50 in serum and pleural fluid is of practical value in the diagnosis, differential diagnosis and monitoring of lung cancer and cancer pleural effusion.