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Heat transfer and vacuum in condenser are influenced by the aerodynamic performance of steam turbine exhaust hood.The current research on exhaust hood is mainly focused on analyzing flow loss and optimal design of its structure without consideration of the wet steam condensing flow and the exhaust hood coupled with the front and rear parts.To better understand the aerodynamic performance influenced by the tilt angle of flow guide inside a diffuser,taking a 600 MW steam turbine as an example,a numerical simulator CFX is adopted to solve compressible three-dimensional (3D) Reynolds time-averaged N-S equations and standard k-e turbulence model.And the exhaust hood flow field influenced by different tilt angles of flow guide is investigated with consideration of the wet steam condensing flow and the exhaust hood coupled with the last stage blades and the condenser throat.The result shows that the total pressure loss coefficient and the static pressure recovery coefficient of exhaust hood change regularly and monotonously with the gradual increase of tilt angle of flow guide.When the tilt angle of flow guide is within the range of 30° to 40°,the static pressure recovery coefficient is in the range of 15.27％ to 17.03％ and the total pressure loss coefficient drops to approximately 51％,the aerodynamic performance of exhaust hood is significantly improved.And the effective enthalpy drop in steam turbine increases by 0.228％ to 0.274％.It is feasible to obtain a reasonable title angle of flow guide by the method of coupling the last stage and the condenser throat to exhaust hood in combination of the wet steam model,which provides a practical guidance to flow guide transformation and optimal design in exhaust hood.