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最近研究发现噻嗪类利尿剂有预防和治疗骨质疏松症的双重作用.经噻嗪治疗的绝经后妇女骨密度要比未治疗的对照组高;男、女患者使用噻嗪利尿后骨丢失率均可降低。长期服用可减少骨折危险,但是有关噻嗪类利尿剂对骨吸收的作用尚不清楚。空腹尿羟脯氨酸已广泛用作骨吸收的一个指标。作者进一步探索氯噻嗪对正常绝经后妇女短期使用后,尿羟脯氨酸及其它骨代谢有关生化指标变化情况。 14名健康绝经后妇女作为受试者,平均年龄65岁(范圈47～77),平均体重64kg(范围49～101)。凡有各种明显疾患、长期服用过雌激素、孕激素、补
A recent study found that thiazide diuretics have a dual role in the prevention and treatment of osteoporosis.Postmenopausal women treated with thiazide have higher bone mineral density than untreated controls and bone loss in both men and women with thiazide diuretic Rate can be reduced. Long-term use can reduce the risk of fracture, but the role of thiazide diuretics on bone resorption is unclear. Fasting urinary hydroxyproline has been widely used as an indicator of bone resorption. The authors further explore the biochemical changes of urinary hydroxyproline and other bone metabolism following the short-term use of chlorothiazide for normal postmenopausal women. Fourteen healthy post-menopausal women, mean age 65 years (range 47-77), averaged 64 kg (range, 49-101) as subjects. Where there are a variety of obvious diseases, long-term use of estrogen, progesterone, make up