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目的探讨血清脑钠肽(BNP)和超敏C反应蛋白(hsCRP)在2型糖尿病(T2DM)合并冠心病中的诊断价值。方法将64例T2DM合并冠心病患者(A组)按临床类型分为急性心肌梗死组(A1组,22例)、不稳定型心绞痛组(A2组,21例)和稳定型心绞痛组(A3组,21例);另选取64例T2DM不合并冠心病者作为对照(B组)。检测各组BNP、hsCRP和糖化血红蛋白(HbA1c)等水平。结果 A组患者HbA1c、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、BNP[(216.00±31.53)ng/L vs.(29.00±4.20)ng/L]和hsCRP[(6.12±1.10)mg/L vs.(0.91±0.31)mg/L]水平均高于B组(P<0.01)。A1、A2和A3组间BNP和hsCRP水平差异亦有统计学意义(P<0.01)。A组患者血清BNP与hsCRP、HbA1c呈正相关(r=0.314、0.376,P<0.05),血清HbA1c与hsCRP表达亦呈正相关(r=0.576,P<0.01)。结论 T2DM合并冠心病患者血清BNP和hsCRP水平均明显增高。两者联合测定对诊断T2DM合并冠心病具有重要意义。
Objective To investigate the diagnostic value of serum brain natriuretic peptide (BNP) and high sensitivity C-reactive protein (hsCRP) in type 2 diabetes mellitus (T2DM) with coronary heart disease. Methods Sixty-four T2DM patients with coronary heart disease (group A) were divided into two groups according to clinical types: acute myocardial infarction (group A1, n = 22), unstable angina (group A2, n = 21) , 21 cases). Another 64 patients with T2DM without coronary heart disease were selected as control (group B). The levels of BNP, hsCRP and HbA1c in each group were detected. Results The levels of HbA1c, TC, LDL-C, BNP [(216.00 ± 31.53) ng / L vs. (29.00 ± 4.20) ng / L] and hsCRP [(6.12 ± 1.10 ) mg / L vs. (0.91 ± 0.31) mg / L] were higher than those in group B (P <0.01). There was also a significant difference in the levels of BNP and hsCRP between A1, A2 and A3 (P <0.01). Serum BNP was positively correlated with hsCRP and HbA1c in group A (r = 0.314,0.376, P <0.05), and serum hbA1c was also positively correlated with hsCRP (r = 0.576, P <0.01). Conclusion The levels of serum BNP and hsCRP in T2DM patients with coronary heart disease were significantly higher. Combined determination of the two of the diagnosis of T2DM with coronary heart disease is of great significance.