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目的:探讨万古霉素在临床治疗中患者的血药浓度情况。方法:以2005年至2012年我院的40例万古霉素使用者来进行研究分析,他们用药后,接受了血药浓度检测,对患者的病历情况、年龄、性别等等情况均进行了详细记录,结合患者的用药情况和血药浓度进行综合研究分析。结果:这些患者中治疗有效率为70%,其万古霉素DUI是0.79,性别的差异在血药浓度和谷浓度不会产生影响,患者的肾功能是影响万古霉素的峰浓度主要影响因素,肾功能正常以及肾功能不全的患者对比其万古霉素谷浓度差异性不大。结论:临床中进行万古霉素的血药浓度研究,发现,肾功能是影响其血药浓度的一个重要因素,因此使用该药物的时候需要考虑到患者的肾功能情况,提前进行药物的调整。
Objective: To investigate the plasma concentration of vancomycin in patients undergoing clinical treatment. Methods: Forty vancomycin users in our hospital from 2005 to 2012 were analyzed. After receiving the drug, they were tested for the blood concentration, and the patient’s medical history, age, gender and so on were detailed Record, combined with the patient’s medication and plasma concentration for comprehensive study. RESULTS: The response rate was 70% in these patients and its vancomycin DUI was 0.79. The difference in sex did not affect plasma concentration and trough concentration. The renal function of patients was the main factor influencing the peak concentration of vancomycin , Normal renal function and renal insufficiency in patients with vancomycin Valley concentration difference is not. Conclusion: The clinical study of vancomycin plasma concentration, found that renal function is an important factor affecting the plasma concentration, so the use of the drug need to take into account the patient’s renal function, the advance drug adjustment.