益气滋肾冲剂 (由生黄芪、生地黄、太子参、旱莲草、当归、白芍、银花、芡实等组成 )对IgA肾病有较好疗效。为进一步探讨其作用机理 ,采用牛血清白蛋白 (BSA)致IgA肾病小鼠模型 ,观察其高 ( 0 3 0ml/ 1 0g体重 )、低( 0 1 5ml/ 1 0g体重 )剂量对模型小鼠蛋白尿、肾功能及血脂的影响 ,并与肾炎四味片作对照。结果显示高剂量的益气滋肾冲剂能明显减少蛋白尿 ,对预防低白蛋白血症和高脂血症及肾小球硬化有一定功效 ,具有保护肾功能的良好作用 ,疗效优于肾炎四味片 Yiqi Zishen Granules (composed of Radix Astragali, Radix Rehmanniae, Radix Paeoniae Alba, Eclipta prostrata, Angelica, Angelica, Yinhua, and Gorgoniae) has a good effect on IgA nephropathy. To further explore its mechanism of action, a mouse model of IgA nephropathy induced by bovine serum albumin (BSA) was used to observe its high (0.3 ml/100 g body weight) and low (0.015 ml/100 g body weight) doses in model mice. The effects of proteinuria, renal function and blood lipids were compared with nephritis four taste tablets. The results showed that high-dose Yiqi Zishen Granules can significantly reduce proteinuria, have a certain effect on the prevention of hypoalbuminemia and hyperlipidemia and glomerulosclerosis, have a good effect of protecting renal function, the effect is better than nephritis four Flavor