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目的探讨炎症型多器官功能障碍综合征（ＭＯＤＳ）早期诊断的临床预警指标。方法总结我院近十年１２７例多器官功能衰竭（ＭＯＦ）病人，对其中５９例炎症型病人进行不同时间段的血液化学连续检测。结果同步性变化与ＭＯＦ发生呈相关性变化（ｒ＝０．７２）示ＭＯＤＳ早期阶段血液化学“衰竭”的可能性，同时在此阶段给予抗凝溶栓治疗，发现对照组与治疗组病死率差异显著（Ｐ＜０．０５）。结论ＭＯＤＳ早期存在血液化学“衰竭”，此时用抗凝溶栓治疗，可使ＭＯＤＳ病情发生逆转，降低病死率，为炎症型ＭＯＤＳ提供早期诊断的预警指标。
Objective To explore the clinical early warning indicators of early diagnosis of inflammatory organ dysfunction syndrome (MODS). Methods A total of 127 patients with multiple organ failure (MOF) in our hospital in recent ten years were enrolled. Fifty-nine patients with inflammatory diseases were continuously tested for blood chemistry at different time points. Results The change of synchronicity was correlated with the occurrence of MOF (r = 0.72), indicating the possibility of blood chemistry “failure” in the early stage of MODS. At the same time, anticoagulant thrombolytic therapy was given at this stage. The mortality of the control group and the treatment group The difference was significant (P <0.05). Conclusions Blood chemistry “failure” exists in the early stage of MODS. At this time, anticoagulant thrombolytic therapy can reverse the condition of MODS, reduce the mortality and provide an early warning index for the early diagnosis of inflammatory MODS.