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由于抗菌药物的滥用,细菌耐药性越来越严重,其中耐甲氧西林金黄色葡萄球菌(MRSA)因其具有广泛的耐药性已成为目前医院感染的重要致病菌之一,其所诱发的感染发病率也在迅速增加。MRSA形成的生物被膜有助于其在各种不良的生存环境下得以存活,其渗透障碍作用更能抵抗抗菌药物的渗入,使得MRSA对抗菌药物不敏感,耐药性有所增强从而加重感染。MRSA生物被膜的形成需要相关基因进行调控。因此本文主要通过对生物被膜形成过程中相关基因对其调控机制的研究进展进行概述。
Due to the abuse of antibiotics, bacterial resistance is more and more serious, of which methicillin-resistant Staphylococcus aureus (MRSA) because of its wide range of drug resistance has become one of the important pathogenic bacteria in hospital infection, The incidence of infections is also rapidly increasing. The biofilm formed by MRSA can help its survival in various adverse living conditions. Its osmotic barrier is more resistant to the infiltration of antibiotics, making MRSA insensitive to antibacterial drugs and increasing its resistance, thereby aggravating the infection. The formation of MRSA biofilm requires the regulation of related genes. Therefore, this article mainly through the biofilm formation process related genes regulation mechanism of its research progress.