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为了解急性脑梗死(ACI)患者血浆内皮素(ET)的变化以及龙芪溶栓胶囊对它的影响;对124例急性脑梗死(ACI)患者根据入院时的血压情况随机分为2组:高血压脑梗死组67例(男38例,女29例,年龄46～71岁,平均年龄65岁);单纯脑梗死组57例(男29例,女28例,年龄44～72岁,平均62岁),采用放射免疫法测定血浆ET的浓度并与40例健康对照组比较,其中86例ACI患者接受龙芪溶栓胶囊治疗,2粒/次,3次/d,3周后复查ET。结果2组病人血浆ET浓度分别为(142±26)ng/L和(84±36)ng/L。龙芪溶栓胶囊治疗后(92±57)ng/L和(61±25)ng/L(P<0.01),均高于对照组;结果提示血浆ET水平与血压和病情严重程度有关,ET和ACI有密切关系,早期应用龙芪溶栓胶囊可明显降低ET。
To understand the changes of plasma endothelin (ET) in patients with acute cerebral infarction (ACI) and the effect of Longqi thrombosis capsule on it; 124 patients with acute cerebral infarction (ACI) were randomly divided into two groups according to their blood pressure: There were 67 cases of hypertensive cerebral infarction (38 males and 29 females, aged 46-71 years, mean age 65 years); 57 cases of simple cerebral infarction (29 males and 28 females, aged 44-72 years, mean 62 years old). The concentration of plasma ET was determined by radioimmunoassay and compared with 40 healthy controls. 86 patients with ACI received Longqi thrombolytic capsule treatment, 2 capsules / time, 3 times / d, and after 3 weeks, ET . Results The plasma concentrations of ET in the two groups were (142 ± 26) ng / L and (84 ± 36) ng / L, respectively. (92 ± 57) ng / L and (61 ± 25) ng / L respectively (all P <0.01), all of which were higher than those of the control group. The results suggested that the plasma ET level was related to the blood pressure and the severity of the disease. ET And ACI are closely related to the early application of Longqi thrombolytic capsules can significantly reduce ET.