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目的分析联合检测胸水 INF-γ、ADA、CEA、CA125在良恶性胸腔积液鉴别诊断中的价值体会。方法选择我院2014年9月~2015年8月之间收治的66例胸腔积液患者作为观察对象，根据患者的病理学检查结果分为良性组36例与恶性组30例，对患者胸水中的 INF-γ、ADA、CEA、CA125成分活性进行检测，对比两组的结果差异。结果恶性组30例患者的肿瘤标志物 CA125与 CEA 水平高于良性组，差异显著(<0.05)；同时，恶性组患者的 INF-γ与 ADA 表达水平低于良性组，差异同样具有显著性(<0.05)。结论对胸腔积液患者进行 INF-γ、ADA、CEA、CA125指标的检测，对于鉴别疾病的良性与恶性程度具有重要意义。“,”Objective To analysis of combined detection of pleural effusion INF - gamma, ADA, CEA, CA125 in benign and malignant pleural effusion in the differential diagnosis value of experience. Methods From September 2014 to August 2015 between 66 patients with pleural effusion were treated as research object, according to the pathology examination result into group of 36 cases of benign and malignant groups, 30 cases of patients with breast in the water INF activity, ADA, CEA, CA125 ingredients - both for testing, comparing differences between the results of two groups. Results 30 cases of tumor markers in patients with malignant group, CA125 and CEA levels higher than in benign group, significant difference ( < 0.05); At the same time, the patients with malignant group INF - gamma and ADA expression level is lower than the benign group, also has a significant difference ( < 0.05). Conclusion In patients with pleural effusion for INF - gamma, ADA, CEA, CA125 detection indicators and for differentiating benign and malignant degree is of great significance of the disease.