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本实验使用低浓度氚水(9.25×10~(?)-3.7×10~6Bq/mL)诱发中国仓鼠肺(CHL-1)细胞恶性转化,实验中作了不同时间的照射(24、48、72、96h),累积吸收剂量为0.055—0.88Gy。实验结果表明,氚水在此剂量范围引起该细胞的恶性转化率为3.28%—13.0%。实验中平行使用~(137)Csγ射线照射诱发该细胞恶性转化,剂量率为0.359Gy/d,照射时间与氚水组相同,累积吸收剂量为0.359—1.44Gy。γ射线在此剂量范围引起该细胞的恶性转化率为2.59%—13.4%。上述结果说明,两者的转化率与剂量相关。根据上述两种射线诱发 CHL-1细胞恶性转化率,求出氚水相对于γ射线的相对生物效应(RBE)为1.6。实验中同时作了形态学观察和细胞移植于动物的实验,实验结果都证明了转化了的细胞具有恶性细胞的形态和行为。
In this study, malignant transformation of Chinese hamster lung (CHL-1) cells was induced by low concentration of tritiated water (9.25 × 10 ~ (3.7 × 10 ~ 6Bq / mL) 72,96h), cumulative absorbed dose of 0.055-0.88Gy. The experimental results show that tritiated water in this dose range caused the malignant transformation rate of the cells was 3.28% -13.0%. In the experiment, 137Cs Cs irradiation was used in parallel to induce the malignant transformation, the dose rate was 0.359Gy / d and the irradiation time was the same as that of tritiated water group. The absorbed dose was 0.359-1.44Gy. Gamma rays caused a malignant conversion of this cell range of 2.59% -13.4% at this dose range. The above results show that the conversion rate of the two is dose-dependent. According to the malignant transformation rate of CHL-1 cells induced by the above two kinds of radiation, the relative biological effect (RBE) of the tritiated water relative to the γ-ray was found to be 1.6. Experiments were made both morphological observation and cell transplantation in animal experiments, the experimental results have proved that the transformed cells have the morphology and behavior of malignant cells.