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目的观察羟基喜树碱(HCPT)联合奥沙利铂(L-OHP)5-氟脲嘧啶(5-Fu)治疗晚期直肠癌的疗效。方法经手术或病理组织学证实为晚期直肠癌66例,随机分成对照组用L-OHP5-Fu3周方案治疗晚期直肠癌33例,实验组用HCPT联合L-OHP5-Fu治疗晚期直肠癌33例,比较两组患者疾病相关临床症状改善,疗效和毒副反应情况。结果实验组部分缓解率(PR)为48.5%,半年及1年生存率分别为90.9%、27.3%;中位生存期为13个月,对照组(PR)为42.4%,半年及1年生存率分别为63.7%、18.2%;中位生存期为9.3个月,两组均有不同程度的胃肠道反应及骨髓抑制等不良反应(P:0.10,P:0.945,P﹥0.05),两组比较差异无统计学意义。结论 HCPT联合L-OHP5-Fu方案治疗晚期直肠癌,能有效的改善患者的生存质量,延长患者的生命,毒副反应可以耐受。
Objective To observe the effect of HCPT and L-OHP 5-Fu on advanced rectal cancer. Methods Sixty-six patients with advanced rectal cancer confirmed by operation or histopathology were randomly divided into control group (n = 33) treated with L-OHP5-Fu3weeks for 33 cases of advanced rectal cancer and experimental group treated with HCPT combined with L-OHP5-Fu for 33 cases of advanced rectal cancer , To compare the two groups of patients with disease-related clinical symptoms, efficacy and toxicity. Results The partial remission rate (PR) in the experimental group was 48.5%, and the half-year and 1-year survival rates were 90.9% and 27.3% respectively. The median survival time was 13 months and the control group (PR) was 42.4% Rates were 63.7% and 18.2%, respectively. The median survival time was 9.3 months. Both groups had different degrees of adverse reactions such as gastrointestinal reactions and bone marrow suppression (P = 0.10, P = 0.945, P> 0.05) There was no significant difference between the two groups Conclusion HCPT combined with L-OHP5-Fu regimen in the treatment of advanced rectal cancer can effectively improve the quality of life of patients and prolong the life of patients. Toxic and side effects can be tolerated.