论文部分内容阅读
目的观察川芎嗪注射液对新生儿硬肿症(SN)患儿血胱抑素C(Cys C)的影响。方法 69例SN患儿为SN组,30名新生儿为对照组。SN患儿中轻度患儿39例,中重度患儿30例。轻度、中重度患儿采用随机数字表法分为治疗组与常规组,常规组采用常规支持疗法和对症处理,治疗组在常规组治疗基础上加用川芎嗪注射液6mg/kg(加入5%葡萄糖注射液30mL静脉滴注),每日1次,均治疗7日。检测血Cys C与BUN、Cr水平,计算Cys C与BUN、Cr异常率,并进行相关关系分析。同时观察各组患儿硬肿消退时间。结果与对照组比较,SN组治疗前血Cys C明显升高(t=10.55,P<0.01),而BUN、Cr与对照组比较,差异无统计学意义(t=1.50,1.73;P>0.05);与轻度患儿比较,中重度患儿血Cys C明显升高(t=2.11,P<0.05),BUN、Cr虽有增高趋势,但差异无统计学意义(t=2.07,1.92;P>0.05)。经直线相关分析,SN组血清Cys C与BUN、Cr分别存在正相关关系(r=0.314,0.287;P<0.05)。SN患儿Cys C、BUN、Cr的异常率为72.5%(50/69)、27.5%(19/69)及36.2%(25/69),Cys C的异常率显著高于BUN、Cr(χ2=41.04,P<0.01)。治疗后,与常规组比较,SN轻度、中重度患儿治疗组血Cys C水平及硬肿消退时间明显下降(P<0.05),BUN、Cr则差异无统计学意义(P>0.05)。结论血Cys C可早期反映SN患儿肾功能损害,而川芎嗪注射液可以明显降低血Cys C水平,促进硬肿症新生儿肾损害的恢复,缩短硬肿消退时间。
Objective To investigate the effects of ligustrazine injection on cystatin C (Cys C) in neonates with sclerema (SN). Methods 69 cases of SN children were SN group, 30 newborns as control group. 39 cases of mild children with SN, 30 cases of moderate and severe children. Mild, moderate and severe children were divided into treatment group and conventional group by random number table. The conventional group was treated with conventional supportive therapy and symptomatic treatment. The treatment group was treated with ligustrazine injection 6mg / kg % Glucose injection 30mL intravenous infusion), once daily, were treated for 7 days. The levels of Cys C, BUN and Cr in blood were detected, and the abnormal rates of Cys C, BUN and Cr were calculated, and the correlation analysis was carried out. At the same time, each group of children with sclerosis dissipated time. Results Compared with the control group, the Cys C in SN group was significantly increased (t = 10.55, P <0.01), but there was no significant difference between BUN and Cr group (t = 1.50,1.73; P> 0.05 (T = 2.11, P <0.05). The levels of BUN and Cr in the children with moderate or severe were higher than those in the mild children without significant difference (t = 2.07, 1.92; P> 0.05). By linear correlation analysis, there was a positive correlation between serum Cys C and BUN, Cr in SN group (r = 0.314,0.287, P <0.05). The abnormal rates of Cys C, BUN and Cr in children with SN were 72.5% (50/69), 27.5% (19/69) and 36.2% (25/69) respectively, and the abnormal rates of Cys C were significantly higher than those of BUN and Cr = 41.04, P <0.01). After treatment, compared with the control group, the level of Cys C and the time to resolution of edema and edema in children with mild or moderate SN were significantly decreased (P <0.05), while there was no significant difference between BUN and Cr (P> 0.05). Conclusions Blood Cys C can early reflect the renal dysfunction in children with SN. However, Ligustrazine injection can significantly reduce the level of serum Cys C and promote the recovery of renal damage in neonates with sclerema and shorten the time of sclerosis.