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鉴于目前人们高度重视遗传因素对病理过程和预后的影响,这种遗传因素主要指人类白细胞抗原(HLA),又称组织相容性抗原。为此作者对60例浸润型肺结核患者进行了研究,男46,女14例。其中23～35岁的青年患者39例,肺空洞患者56例,排菌患者54例,住院时间长达5～10个月。将患者分成3组:第1组46例为经过治疗空洞闭合排菌停止者;第2组14例病情未得到控制,并向纤维空洞型肺结核发展者;第3组是对照组,为17例纤维空洞型肺结核患者。采用微量淋巴毒试验检测HLA.间接免疫酶分析法检查抗结核菌素IgG 抗体。结果①研究HLA 的A、B、C、DR26个位点抗原出现频率,发现病程经过不良的浸润型肺结核患者HLA A_2、B_(13)、B_(16)、DR_2明显增高;而病情经
Given the current emphasis on genetic factors on the pathological process and prognosis, this genetic factor mainly refers to human leukocyte antigen (HLA), also known as histocompatibility antigen. To this end the author of 60 cases of infiltrative pulmonary tuberculosis patients were studied, 46 males and 14 females. Among them, 39 were young patients aged 23 to 35, 56 were lung empty holes, 54 were discharged bacteria, and the length of hospital stay was 5 to 10 months. The patients were divided into three groups: 46 cases in group 1 were treated with closed cavities and closed their cells; 14 cases in group 2 were uncontrolled and developed fibroblastic pulmonary tuberculosis; group 3 was the control group, 17 cases Fiber hollow tuberculosis patients. Detection of HLA using microlymph lymphotoxin test and anti-tuberculin IgG antibody by indirect immunoenzyme assay. Results ① The frequency of HLA-A, B, C and DR26 antigen spots was studied and found to be significantly increased in HLA-B_2, B_ (13), B_ (16) and DR_2 patients with poor infiltrative pulmonary tuberculosis.