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采用生物活性法和/或酶联免疫吸附法以及乳酸脱氢酶释放法,研究了人类疱疹病毒6型(HHV-6)南京地方株CNS对人外周血单个核细胞(PBMCs)的IL—6、IL-8的诱生和NK活性的影响,并与国外的GS株作比较。结果发现,HHV—6CN8、GS两株病毒感染均可诱导PBMCs产生IL-8,48h达到峰值。两株病毒所诱生的IL-8水平并无显著性差异(P>0.05),并可抑制IL-6的产生,但GS株的抑制作用强于CNS株(P<0.05)。HHV-6体外感染12~24h可以增强NK活性,且CN8株诱导的NK活性高于GS株(P<0.05),之后NK活性逐渐减弱。以上结果提示:HHV-6感染可以通过诱生细胞因子和改变NK活性而影响人的免疫功能,而A组的GS株对免疫功能的抑制作用大于B组的CN8株。
The biological activity and / or enzyme-linked immunosorbent assay (ELISA) and lactate dehydrogenase (LDH) release assay were used to study the effect of human herpesvirus type 6 (HHV-6) , The induction of IL-8 and NK activity, and compared with the foreign GS strains. The results showed that HHV-6CN8, GS two virus infection can induce PBMCs produce IL-8, 48h peak. The levels of IL-8 induced by the two viruses did not differ significantly (P> 0.05), and inhibited the production of IL-6. However, the inhibition of GS strain was stronger than that of CNS strain (P <0.05) . Infection of HHV-6 in vitro for 12-24 h enhanced the activity of NK, and the NK activity induced by CN8 was higher than that of GS (P <0.05), and the activity of NK decreased gradually. The above results suggest that HHV-6 infection can affect human immune function by inducing cytokines and altering NK activity, whereas GS strains in group A have a greater inhibitory effect on immune function than CN8 strain in group B.