生物节律是机体为响应外界环境变化而形成的一种内在自主计时机制，调控机体各项生理活动，影响人体各类疾病的形成与转归。本文阐述了口腔颌面发育畸形、炎症、恶性肿瘤等常见疾病状态下局部组织活动节律的变化规律，辩证分析生物钟系统及生物节律对口腔颌面组织活动的重要性，重点剖析生物节律在维持口腔健康以及影响口腔常见疾病、口腔相关系统性疾病进程中的作用机制；同时，总结并展望基于组织活动生物节律变化的口腔相关疾病时辰疗法及新型防治策略，为维护口腔健康及全身健康提供新思路。“,”Circadian rhythm is an internal autonomous timing mechanism formed by the body in response to changes of external environment. It participates in the regulations of various physiological activities, affecting the formation and outcome of various diseases in the human body. This paper summarizes the changes of local tissue rhythms in common disease states, such as oral and maxillofacial malformations, inflammation and malignant tumors. The importance of circadian clock system to the activities of oral and maxillofacial tissues are dialectically analyzed, mainly on the mechanisms of action in maintaining oral health and in affecting the processes of common oral diseases and oral-related systemic diseases. At the same time, chronological therapy and new strategies of prevention and treatment for oral-related diseases based on the changes in tissue rhythm are summarized and prospected to provide new ideas for maintaining oral and systemic health.