In this paper,we proposed a registration method by combining the morphological component analysis (MCA) and scale-invariant feature transform (SIFT) algorithm.This method uses the perception dictionaries,and combines the Basis-Pursuit algorithm and the Total-Variation regularization scheme to extract the cartoon part containing basic geometrical information from the original image,and is stable and unsusceptible to noise interference.Then a smaller number of the distinctive key points will be obtained by using the SIFT algorithm based on the cartoon part of the original image.Matching the key points by the constrained Euclidean distance,we will obtain a more correct and robust matching result.The experimental results show that the geometrical transform parameters inferred by the matched key points based on MCA+SIFT registration method are more exact than the ones based on the direct SIFT algorithm.