药物治疗有时可引起自身免疫和自身免疫性疾病。两种抗高血压药物—甲基多巴和肼苯哒嗪,可以引起自身免疫性Coombs′实验阳性溶血性贫血和系统性红斑狼疮(SLE)样综合征。溶血性贫血是应用甲基多巴治疗的主要并发症,而SLE综合征于肼苯哒嗪治疗的病人中更为普遍。甲基多巴引起的溶血性贫血另有讨论,这里就肼苯哒嗪的免疫学副作用予以综述。 Medications can sometimes cause autoimmune and autoimmune diseases. Two antihypertensives, methyldopa and hydralazine, can cause autoimmune Coombs’ experimental hemolytic anemia and systemic lupus erythematosus (SLE) -like syndrome. Hemolytic anemia is a major complication of treatment with methyldopa, whereas SLE syndrome is more prevalent in patients treated with hydralazine. Another discussion of hemolytic anemia caused by methyldopa, here to summarize the immunological side effects of hydralazine.