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利用PCR技术检测了24例何杰金病例中的t（14；18），又利用免疫组织化学方法检测了64例何杰金病例中Bcl－2蛋白的表达，并利用上述两种方法对10例反应性增生淋巴结进行了对照检测，结果30％何杰金病例为t（14；18）阳性，同时在2例有明显滤泡增生的反应性增生淋巴结中也检出了这种易位。因此不能确定何杰金病例中的t（14；18）是否来源于肿瘤细胞。此外发现在仅使用mbr引物的条件下，t（14；18）与Bcl－2蛋白高表达之间并无相互对应的关系。
The detection of t (14; 18) in 24 cases of Hodgkin’s disease was performed by PCR, and the expression of Bcl-2 protein in 64 Hodgkin’s cases was detected by immunohistochemistry. Cases of reactive hyperplastic lymph nodes were controlled test, the results of 30% of Hodgkin’s cases t (14; 18) positive, while in 2 cases of follicular hyperplasia of reactive hyperplasia lymph nodes were also detected this translocation. It is therefore not certain whether H (14; 18) in Hodgkin’s disease is derived from tumor cells. In addition, it was found that there was no reciprocal relationship between t (14; 18) and high expression of Bcl-2 protein using only the mbr primer.