论文部分内容阅读
目的分析胃肠道间质瘤(GIST)的临床病理特点及免疫组化特征。方法收集2012年7月—2014年10月临汾市人民医院收治的86例GIST患者的病例及肿瘤切除标本。采用免疫组织化学SP法分析内皮细胞标记(CD34)、酪氨酸激酶生长因子受体蛋白(CD117)、肌动蛋白(SMA)、神经元特异性烯醇化酶(NSE)及神经元特异性抗体(S-100)的抗体表达情况,并观察GIST的病理特点(肿瘤大小、组织学类型、生长部位、核分裂象)。结果 CD117和CD34表达程度极高,阳性率分别为90.70%、60.47%,S-100、SMA呈局灶状阳性,阳性率分别为15.12%、18.60%;肿瘤生长部位:胃48例、结肠18例、小肠15例、食管5例;根据肿瘤核分裂像和大小判断肿瘤危险度:极低度16例、低度23例,中度20例、高度27例。结论胃肠道间质瘤多发生在胃部,肿瘤大小、核分裂像、组织学特征及CD34、CD117的表达情况有助于疾病诊断和治疗。
Objective To analyze the clinicopathological features and immunohistochemical features of gastrointestinal stromal tumors (GISTs). Methods Totally 86 cases of GIST patients and tumor resection specimens collected from Linfen People’s Hospital from July 2012 to October 2014 were collected. The expression of endothelial cell marker (CD34), tyrosine kinase growth factor receptor protein (CD117), actin (SMA), neuron specific enolase (NSE) and neuron specific antibody (S-100) antibody expression, and to observe the pathological features of GIST (tumor size, histological type, growth sites, mitosis). Results The positive expression rates of CD117 and CD34 were 90.70% and 60.47% respectively. The positive rates of S-100 and SMA were focal and the positive rates were 15.12% and 18.60% respectively. The tumor growth sites were 48 cases of stomach and 18 cases of colon Cases of small intestine in 15 cases, 5 cases of esophagus; According to the tumor mitosis size and size to determine the tumor risk: extremely low in 16 cases, low in 23 cases, moderate in 20 cases, 27 cases in height. Conclusions Gastrointestinal stromal tumors often occur in the stomach, tumor size, mitosis, histological features and the expression of CD34 and CD117 contribute to the diagnosis and treatment of the disease.