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本文通过实验观察地戈辛(DX)有效治疗浓度水平,克山病为1.47±0.39ng/ml,其他心脏病为1.84±0.53ng/ml,两者无统计学差异。每日投给 DX0.25mg 维持量,5天可接近有效治疗浓度,7天达有效治疗浓度;每日投给 DX0.5mg 或0.75mg,于2—3天即可达有效治疗浓度,后再改每日0.25mg 维持。DX 中毒浓度水平为2.5ng/ml 以上。未看出不同投药方法与中毒间的关系。指出测定血中 DX 浓度对合理使用 DX 有重要意义。DX 达有效治疗浓度后,可见红细胞内 Na~+显著增加,为研究 DX 作用机理和有效浓度指标提供线索。
In this paper, the experimental treatment of digoxin (DX) effective treatment levels, Keshan disease was 1.47 ± 0.39ng / ml, other heart disease was 1.84 ± 0.53ng / ml, both no significant difference. Dosing DX0.25mg daily maintenance dose, 5 days can be close to the effective treatment concentration, 7 days of effective treatment concentration; daily dosing DX0.5mg or 0.75mg, in 2-3 days up to the effective treatment concentration, and then Change 0.25mg daily maintenance. DX poisoning concentration level of 2.5ng / ml or more. The relationship between different methods of administration and poisoning is not seen. Pointed out that the determination of DX concentration in blood is of great importance to the rational use of DX. After the effective therapeutic concentration of DX was reached, Na ~ + in erythrocytes was significantly increased, providing clues for studying the mechanism of DX action and effective concentration index.