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[目的]观察雷贝拉唑、阿莫西林、替硝唑三联疗法治疗十二指肠溃疡(DU)的疗效。[方法]将120例幽门螺杆菌(Hp)阳性的DU患者随机分为2组,各60例,治疗组,采用雷贝拉唑三联疗法治疗,对照组采用奥美拉唑三联疗法治疗,2组患者均服药4周,并在停药4周后复查胃镜及Hp,比较2组溃疡愈合率及Hp根除率。[结果]治疗组溃疡愈合率88.33%,对照组85.00%,2组比较差异无统计学意义(P>0.05);治疗组Hp根除率91.67%,对照组78.33%,2组比较差异有统计学意义(P<0.05)。[结论]雷贝拉唑三联疗法根除Hp治疗DU优于奥美拉唑三联疗法。
[Objective] To observe the curative effect of rabeprazole, amoxicillin and tinidazole triple therapy on duodenal ulcer (DU). [Methods] 120 cases of Hp-positive DU patients were randomly divided into two groups of 60 cases each, treated with rabeprazole triple therapy and the control group treated with omeprazole triple therapy. 2 The patients in the two groups took medication for 4 weeks, and the gastroscope and Hp were examined after stopping for 4 weeks. The healing rate and Hp eradication rate were compared between the two groups. [Results] The healing rate of ulcer in treatment group was 88.33%, while that of control group was 85.00%. There was no significant difference between the two groups (P> 0.05). The eradication rate of Hp in treatment group was 91.67% and that in control group was 78.33% Significance (P <0.05). [Conclusion] Rabeprazole triple therapy is superior to omeprazole triple therapy in the treatment of DU with Hp.