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以奎宁为拆分剂,在甲醇溶液中,将O-乙基-O-苯基硫代磷酸(Ⅰ)拆分成一对对映异构体。 旋光活性的酸在醇钠存在下与卤代烷反应,得到O-乙基-O-苯基-S-烷基硫代磷酸酯(Ⅱ)的对映异构体。 其中Ⅱ-b和Ⅱ-c两对对映异构体为杀虫剂。
Using quinine as a resolving agent, O-ethyl-O-phenyl phosphorothioate (I) was resolved into a pair of enantiomers in methanol solution. The optically active acid is reacted with alkyl halide in the presence of sodium alcoholate to give the enantiomer of O-ethyl-O-phenyl-S-alkyl phosphorothioate (II). Among them, the two enantiomers Ⅱ-b and Ⅱ-c are insecticides.