在兔股骨粉碎性骨折创伤模型上观察了川芎嗪的保护效应。发现动物创伤后，血压呈进行性降低趋势，逐渐陷入休克低血压状态。并出现血浆乳酸脱氢酶（ＬＤＨ）及组织蛋白酶Ｄ（ＣＤ）活性增高的组织损伤表现和肺水肿、胃粘膜缺损等器官损伤表现，与此同时血浆和组织脂质过氧化产物丙二醛（ＭＤＡ）含量及组织细胞内钙含量均增高。而应用川芎嗪进行防治，则上述损伤变化明显减轻。防止了创伤性休克的发生和发展。提示：川芎嗪具有抗创伤效应。 The protective effect of tetramethylpyrazine was observed on rabbit femur comminuted fracture model. After the animals were found to be traumatized, the blood pressure showed a progressive decrease and gradually fell into shock hypotension. In addition, the expression of plasma lactate dehydrogenase (LDH) and cathepsin D (CD) increased the performance of tissue damage and the performance of pulmonary edema, gastric mucosal defects and other organ damage, while plasma and tissue lipid peroxidation products malondialdehyde ( MDA) content and intracellular calcium content increased. The use of tetramethylpyrazine for prevention and treatment, the damage changes significantly reduced. Prevent the occurrence and development of traumatic shock. Tip: Ligustrazine has an anti-injury effect.