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目的探讨卵巢类癌的临床病理、免疫组化特点及其与预后的关系。方法对10例卵巢类癌临床及病理资料进行复习,应用SP法免疫组织化学染色并随访。结果患者年龄26~72岁。肿块部位:右侧卵巢7例,左侧卵巢3例。光镜下癌细胞大小、形状、染色较一致,排列呈实性小巢状或岛状、梁状、腺泡状。10例CK、Syn均为(+),7例NSE、CgA为(+)。TG、TTF-1、α-inhibin、ER和PR均(-)。7例获随访者均存活。结论卵巢类癌是少见的卵巢单胚层畸胎瘤,生物学行为低度恶性,需结合组织病理形态、免疫组织化学染色和临床资料对卵巢原发性类癌进行诊断和鉴别诊断。
Objective To investigate the clinicopathological and immunohistochemical characteristics of ovarian carcinoid and its relationship with prognosis. Methods The clinical and pathological data of 10 patients with ovarian carcinoid were reviewed. Immunohistochemical staining and follow - up were performed by SP method. Results Patients aged 26 to 72 years old. Tumor site: right ovary in 7 cases, left ovary in 3 cases. Light microscope, the size of the cancer cells, shape, staining more consistent arranged in a solid nests or islands, beam-like, acinar. 10 cases of CK, Syn were (+), 7 cases of NSE, CgA (+). TG, TTF-1, α-inhibin, ER and PR (-). All 7 patients survived. Conclusions Ovarian carcinoid tumor is a rare ovarian monocytic teratoma with low malignant biological behavior. It is necessary to diagnose and differentiate the primary carcinoid ovary by combination of histopathology, immunohistochemical staining and clinical data.