链激酶streptokinase(SK)和尿激酶urokinase(UK)是两种纤维蛋白溶解药。1933年Tillett和Garher发现链激酶,是C群β-溶血性链球菌产生的一种细菌蛋白质,最近已能人工提取。尿激酶是存在于人尿中的纤维蛋白溶解物质,1947年为Macfarlane和Pilling发现,近来已能从组织培养的人类肾细胞中获得。近年来,应用SK治疗静脉血栓形成,肺栓塞和 Streptokinase (SK) and urokinase (UK) are two fibrinolytic drugs. In 1933 Tillett and Garher discovered that streptokinase, a bacterial protein produced by Group C beta-hemolytic streptococcus, has recently been artificially extracted. Urokinase, a fibrinolytic substance found in human urine, was discovered by Macfarlane and Pilling in 1947 and has recently been obtained from tissue cultured human kidney cells. In recent years, the application of SK treatment of venous thrombosis, pulmonary embolism and