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目的 :探讨喉癌患者手术前后血清一氧化氮 (NO)水平变化及其临床意义。方法 :采用硝酸还原酶法对 4 2例喉癌患者、30例声带息肉患者、3例健康人血清 NO水平进行了测定。结果 :喉癌患者血清 NO水平显著高于声带息肉组和正常对照组差异均有显著性 (P均 <0 .0 1)。根治性喉癌切除术后 2周 ,血清 NO水平明显低于术前 (P<0 .0 1)。颈淋巴结转移组明显高于非转移组 (P<0 .0 1)。结论 :喉癌患者在病情发展过程中 ,血清中 NO的合成、释放均有所增加。提示 NO可能参与喉癌患者的肿瘤免疫 ,在喉癌的发生发展中起重要作用。其检测可作为喉癌患者病情变化及预后判断的一项有用指标
Objective: To investigate the changes of serum nitric oxide (NO) level in patients with laryngeal cancer before and after operation and its clinical significance. Methods: Nitric acid reductase method was used to determine serum NO levels in 42 patients with laryngeal cancer, 30 patients with vocal cord polyps and 3 healthy controls. Results: The serum NO level in patients with laryngeal cancer was significantly higher than that in vocal cord polyps and normal controls (all P <0.01). After 2 weeks of radical laryngectomy, the level of serum NO was significantly lower than that before operation (P <0.01). Cervical lymph node metastasis was significantly higher than non-metastasis group (P <0.01). Conclusions: The synthesis and release of nitric oxide in serum of patients with laryngeal cancer are increased during the progression of the disease. Tip NO may participate in the tumor immunity of laryngeal cancer patients, plays an important role in the occurrence and development of laryngeal cancer. Its detection can be used as a useful indicator of changes in the condition of patients with laryngeal cancer and prognosis