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新生儿持续肺动脉高压(Persistent pulmonary hypertensionof the newborn,PPHN)是指新生儿生后肺血管阻力持续性增高,肺动脉压超过体循环动脉压,使由胎儿型循环过渡至正常“成人”型循环发生障碍而引起的心房及(或)动脉导管水平血液的右向左分流,临床上出现严重低氧血症等症状[1]。PPHN于1969年被人们首次认识,因其血流动力学改变类似胎儿循环,故又称为持续胎儿循环(Persistent fetalcirculation,PFC)。而造成这一改变的是生后循环不能适应宫外环境。生后成功的过渡是依靠胎儿期高肺血管阻力的
Persistent pulmonary hypertension of the newborn (PPHN) refers to the persistent increase of pulmonary vascular resistance after neonatal birth, pulmonary arterial pressure surpasses systemic arterial pressure, and the transition from fetal cycle to normal “adult” cycle occurs Obstacles caused by atrial and (or) arterial catheterization of the right-to-left shunt of blood, clinical symptoms such as severe hypoxemia [1]. PPHN was first recognized in 1969, because of its hemodynamic changes similar to fetal circulation, it is also known as persistent fetal circulation (Persistent fetal circulation, PFC). And this change is caused by the cycle of life can not adapt to the extrauterine environment. The successful transition after birth depends on the high pulmonary vascular resistance in the fetus