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目的:通过内关穴注射香丹注射液预处理对大鼠急性心肌缺血纤溶系统t-PA、PAI-1活性的影响,探讨针药结合预防和改善心肌缺血的疗效,以期为临床治疗冠心病心肌缺血提供新的思路和方法。方法:以SD大鼠为受试对象,心肌缺血前给予内关穴注射香丹注射液预处理14天,同时设药物对照组和穴位注射组进行比较;用异丙肾上腺素(ISO)腹腔皮下注射造成心肌缺血模型,采用酶联免疫吸附法(ELISA)检测血浆t-PA、PAI-1含量的变化。结论:内关穴注射香丹注射液预处理可升高t-PA含量、降低PAI-1含量,对急性心肌缺血大鼠的心肌具有保护作用。
OBJECTIVE: To investigate the effect of injection of Xiangdan injection on the activity of t-PA and PAI-1 in rats with acute myocardial ischemia and fibrinolysis, and to explore the therapeutic effect of acupuncture and medicine in preventing and improving myocardial ischemia. Provide new ideas and methods for the treatment of myocardial ischemia of coronary heart disease. Methods: Sprague-Dawley rats were used as the experimental subjects. Before ischemia, Neiguan injection was injected for 14 days. At the same time, the drug control group and the acupoint injection group were compared. The rats were anesthetized with isoproterenol (ISO) Subcutaneous injection of myocardial ischemia model, the use of enzyme-linked immunosorbent assay (ELISA) detection of plasma t-PA, PAI-1 content changes. Conclusion: Neiguan injection of Xiangdan injection pretreatment can increase t-PA content, reduce PAI-1 content, myocardial protection in acute myocardial ischemia rats.