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目的研究老年肝硬化患者不同类型食物胃排空时间及其与血清NO水平关系。方法分别应用实时超声法和放射学方法对30例老年肝硬化患者(Child-Pugh A级9例,B级13例,C级8例)和30例健康志愿者进食液体和半固体食物后胃排空时间进行测定,并测定其空腹血清NO浓度。结果肝硬化患者胃液体半排空时间为47.3±6.9min,而进食10mm小钡条和半固体标准餐混合物后胃排空时间为6.9±1.9 h;健康对照组则分别为26.4±5.3min和4.7±1.1h。血清NO浓度患者组与对照组分别为67.9±7.3umol/L及48.8±6.2umol/L,差异均有统计学意义。而Child A,B,C三组之间差异无统计学意义。结论老年肝硬化患者不同类型食物胃排空时间均有延迟,NO在动力延缓中可能起着重要的作用。实时超声法和放射学方法简单有效。
Objective To study the relationship between gastric emptying time and serum NO levels in elderly patients with liver cirrhosis. Methods 30 cases of elderly patients with cirrhosis (Child-Pugh A grade 9 cases, B grade 13 cases, C grade 8 cases) and 30 healthy volunteers were given liquid and semi-solid food after stomach Emptying time were measured, and determine the fasting serum NO concentration. Results The gastric emptying time of patients with liver cirrhosis was 47.3 ± 6.9min, while the gastric emptying time was 6.9 ± 1.9 h after consuming 10mm barium and semi-solid standard meal mixture, while the healthy control group was 26.4 ± 5.3min and 4.7 ± 1.1h. Serum NO concentration in patients and control groups were 67.9 ± 7.3umol / L and 48.8 ± 6.2umol / L, the differences were statistically significant. There was no significant difference between Child A, B and C groups. Conclusions The gastric emptying time of different types of food in elderly patients with liver cirrhosis is delayed, and NO may play an important role in the dynamic retardation. Real-time ultrasound and radiology methods are simple and effective.