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目的研究迷迭香酸对宫颈癌细胞转移能力的抑制作用及其可能机制。方法用1,5和10μmol·L~(-1)的迷迭香酸分别处理宫颈癌细胞,通过Transwell小室法检测细胞的转移能力、半定量RT-PCR法检测细胞RhoA mRNA的表达、免疫荧光法检测RhoA蛋白的表达情况。结果 5,10μmol·L~(-1)的迷迭香酸可以抑制宫颈癌细胞的转移(P<0.01),而且2组细胞表达RhoA明显减少(P<0.05)。结论迷迭香酸可以抑制宫颈癌细胞的转移能力,其作用机制可能与减少细胞RhoA的表达有关。
Objective To study the inhibitory effect of rosmarinic acid on the metastasis of cervical cancer cells and its possible mechanism. Methods Cervical cancer cells were treated with 1, 5 and 10 μmol·L -1 rosmarinic acid respectively. The cell viability was measured by Transwell chamber assay. The expression of RhoA mRNA was detected by semi-quantitative RT-PCR. Immunofluorescence Method to detect RhoA protein expression. Results Rosmarinic acid 5 and 10 μmol·L -1 could inhibit the metastasis of cervical cancer cells (P <0.01), and the expression of RhoA was significantly decreased in both groups (P <0.05). Conclusion Rosmarinic acid can inhibit the metastasis of cervical cancer cells, and its mechanism may be related to the decrease of RhoA expression.