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目的观察急性冠脉综合征发作期,调脂治疗临床血脂的检验值变化特点,指导临床调脂药物的应用。方法将52例急性冠脉综合征患者以时间阶段分为两组,治疗组36例,对照组16例。治疗组:①入院即查血脂六项;②常规辛伐他汀:血脂异常者(20～40)mg/d,每晚顿服,血脂正常者(10～20)mg/d,每晚顿服;③住院1周～2周复查血脂1次,观察临床血脂变化。对照组血脂达用药标准者,服辛伐他汀;血脂未达用药标准者(TC<4.1mmol/L,LDL-C<2.07mmol/L)不用调脂药,观察临床血脂变化。结果治疗组发病初治血脂“偏低”者占39.9%,调脂后,病情平稳(1～2)周血脂“偏低”者仅占25.00%,即血脂渐升高患者增多。对照组发病初治及病情平稳后均以TC>4.14mmol/L或LDL-C≥2.07mmol/L为起用调脂药的指标。治疗组和对照组用药调脂率有统计学意义(P<0.01)。结论急性冠脉综合征发病期无论血脂值如何,均应及早常规的应用他汀类调脂药,以稳定粥样硬化斑块。
Objective To observe the changes of the test value of clinical lipid profile in the attack of acute coronary syndrome and to guide the application of clinical lipid-lowering drugs. Methods Fifty-two patients with acute coronary syndrome were divided into two groups according to the time period: 36 cases in the treatment group and 16 cases in the control group. The treatment group: ① blood pressure check six admission; ② conventional simvastatin: dyslipidemia (20 ~ 40) mg / d, night meal clothes, normal blood lipid (10 ~ 20) mg / d, ; ③ hospitalization 1 week ~ 2 weeks to review the blood lipid 1 times, observe the changes of clinical blood lipid. In the control group, the blood lipid level reached the standard of treatment, and simvastatin was given. The blood lipid level was not observed when the blood lipid was lower than the standard of medication (TC <4.1mmol / L, LDL-C <2.07mmol / L) Results In the treatment group, the initial blood lipid level was 39.9%, and only 25.00% of the patients with stable blood lipid level (1-2 weeks) after lipid-lowering therapy, ie, the patients with increasing blood lipid level increased . In the control group, the initial treatment and stable disease were TC> 4.14mmol / L or LDL-C≥2.07mmol / L as the index of the use of lipid-lowering drugs. The lipid-lowering rates of the treatment group and the control group were statistically significant (P <0.01). Conclusions Regardless of the serum lipid level during the onset of Acute Coronary Syndrome, statin lipid-lowering agents should be administered as early as possible to stabilize the atherosclerotic plaque.