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Fractalkine (FKN) is the only known chemokinethat fulfils the dual functions of an adhesivemolecule and a soluble chemoattractant.FKNexpression was reported increase in lungs ofpatients with severe pulmonary arterialhypertension,suggesting that FKN may participatein pathogenesis of pulmonary hypertension.Breviscapine is a flavonoid extracted from Erigeronbreviscapus (Vant.) Hand.Mazz.Breviscapine canprevent the development of hypoxic pulmonaryhypertension but the mechanism is unknown.Thisstudy evaluated the role of FKN in the pathogenesisof hypoxic pulmonary hypertension and the effect ofbreviscapine on FKN in hypoxic pulmonary
Fractalkine (FKN) is the only known chemokinethat fulfils the dual functions of an adhesivemolecule and a soluble chemoattractant.FKNexpression was reported increase in lungs ofpatients with severe pulmonary arterialhypertension,suggesting that FKN may participatein pathogenesis of pulmonary hypertension.Breviscapine is a flavonoid extracted from Erigeronbreviscapus (Vant.) Hand.Mazz.Breviscapine canprevent the development of hypoxic pulmonaryhypertension but the mechanism is unknown.ThisstudyResults The role of FKN in the pathogenesis of hypoxic pulmonary hypertension and the effect of breviscapine on FKN in hypoxic pulmonary